Two research articles have been published together with collaborators that exploited adaptive laboratory evolution (ALE) for the first time to improve phenotypes of wild-type Clostridium autoethanogenum. First article led by the ValgepeaLab team with collaborators from Australia, the USA, and Switzerland utilised ALE to engineer superior strains with faster growth, no need for yeast extract, and robust bioreactor performance on CO-containing gases. Second article with collaborators from Australia and the USA developed faster growing strains on CO2+H2 that showed widespread proteome and intracellular metabolome changes. Both works suggest novel targets for metabolic engineering of cell factories.